ERS Respiratory Channel

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Abstract

Asthma-COPD overlap (ACO) is a heterogeneous condition, is identified by the features shared with both asthma and chronic obstructive pulmonary disease (COPD).Serum vitamin D binding protein (VDBP) is known as the protein to carry vitamin D.Some articles reported that VDBP is related to Asthma and COPD.In this study, we measured the serum vitamin D binding protein in a Japanese adult population and compared that between the patients of asthma, COPD, ACO and controls.Methods:30 patients in each groups and 30 normal controls were recruited for this study.We measured the concentration of serum VDBP and compared that between each group.And we measured the count of peripheral blood eosinophils, neutrophils, serum Ca and 25-hydroxyvitamin D (25(OH)D).Spirometry was performed with measurement of forced expiratory volume in 1 s (FEV1) and the forced vital capacity (FVC).We investigated the correlation between serum VDBP and those.Results:The concentration of serum VDBP in asthma patients was higher than that in COPD patients (P<0.01).The concentration of serum VDBP in ACO tended to be lower than that in asthma and higher than that in COPD, but these were no significant differences statistically.The concentration of serum VDBP in controls was lower than that in other groups.There was no significant correlation between serum VDBP and the clinical characteristics in each group.Conclusions:We were the first to analyze serum VDBP in Japanese patients with asthma, COPD and ACO.The concentration of serum VDBP in asthma patients is higher than that in COPD patients.The concentration of serum VDBP in ACO patients tended to be between asthma patients and COPD patients.

Abstract

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