Abstract

Introduction and background: Studies correlating the exhaled fraction of nitric oxide (FeNO) and asthma control questionnaires are controversial, especially in pediatric population. The Asthma Control Test (ACT) and Childhood Asthma Control Test (cACT) are validated questionnaires that evaluate asthma control during the past 4 weeks for children <12 years and ?12 years.

Aims and objectives:  To establish whether a correlation between FeNO and asthma control exists in pediatric patients in Bogotá, Colombia.

Methods: Cross-sectional study including asthma patients 5-17 years of age, attending follow-up at Hospital Militar Central (HMC) between May and November 2022. An initial sociodemographic survey was carried out, followed by c-ACT or ACT as appropriate. FeNO values were quantified with NObreath©.

Results: Eighty-two patients with a median age of 10 years were included, more than half of them male (51.2%). Most patients reported adequate control of the disease (69.5%). In both groups, treatment with Formoterol/Budesonide was predominant (43.8% in the adequate control group vs. 44%). There was no statistical significance difference between disease control and FeNO values in the bivariate analysis and multivariate analysis (p=0.43 and 0.65 respectively). In the multivariate analysis, need for ER visits was less in the controlled group (p=0.02), and history of atopic dermatitis and obstructive sleep apnea were associated to less control of asthma (p=0.029 and 0.24 respectively).

Conclusions: We found no association between FeNO values and self-report of asthma control.