Sarcoidosis is a multisystemic idiopathic inflammatory disorder characterized non-caseating granulomas mainly in lungs and lymph nodes (LLN). T cells, especially CD4 +, play an important role in the pathogenesis of granulomatous inflammation and are a key component of sarcoid granuloma. Twenty-six sarcoidosis patients were enrolled for the study (median age 55 years;[1]  75% were female). Flow-cytometry analysis was performed to detect T cell subsets, especially CCR4- and CXCR3-expressing CD4+ (Th) and CD8+ (Tc) subsets, in peripheral blood (PB), bronchoalveolar lavage (BAL) and lymph node (LLN) from sarcoidosis patients (SP). Th1 cells percentages were higher in BAL than PB (p = 0.0014) and LLN (p = 0.2612). In contrast, peripheral Th2 cells percentages were higher in PB than BAL (p = < 0.001) and LLN (p = 0.0044). The same was found for peripheral Tc1 cells as compared to BAL and LLN (p = 0.0036 and p = 0.0144, respectively). Our study firstly compared T cell subsets in three different anatomical compartments of sarcoidosis patients. Our results confirmed a hallmark of pulmonary sarcoidosis expressed as phenotypic switching of CD4+ cells toward Th1-polarized cells in the lungs, compared to LLN and PB. While peripheral Th2- and Tc1-polarized cells in our sarcoidosis patients were a sign of inflammation similar to what happens in autoimmune diseases. Thus, our study supported the hypothesis of a relationship between autoimmune diseases and sarcoidosis.