Introduction: Bone health in sarcoidosis can be altered due to inflammation, bone involvement or treatment.
Aim: To investigate change in BMD over time in Danish patients with sarcoidosis.
Methods: In 117 patients with sarcoidosis, BMD was measured twice with 12 months interval. T-scores and change in scores were compared between glucocorticoid treated and non-treated patients.
Results: Mean age of the patients was 47 years, 57% were men, 35% were treated with prednisolone and 16% with bisphosphonate. BMD increased over time, Table 1. No difference in mean change of T-score was observed between glucocorticoid treatment groups. Hip: -0.02 (-0.20; 0.17, p= 0.8642) and columna (col): -0.03 (-0.22; 0.16, p= 0.7619). For columna the increase was associated with male gender: 0.28 (0.01; 0.49, p= 0.0022) and bisphosphonate treatment: 0.25 (0.01; 0.49, p=0.0418).
|
T-score |
Baseline | 12 months | Difference |
|
Hip, all Hip +glu n=46 Hip ÷glu n=71 |
-0.13 (-.32; 0.05) -0.10 (-0.39; 0.19) -0.15 (-0.40; 0.09) |
0.07 (-0.13; 0.27) 0.12 (-0.20; .44) 0.05 (-.021; 0.31) |
0.21 (0.12; 0.29) p= 0.0000 0.22 (0.04; 0.39) p=0.0181 0.20 (0.10; 0.30)p=0.0002 |
|
Col, all Col +glu n=46 Col ÷glu n=71 |
-0.4 (-0.63; -0.17) -0.50 (-0.90; -0.13) -0.3 (-0.65; -0.04) |
-0.28 (-0.50; -0.055) -0.35 (-0.68; -0.03) -0.23 (-0.53; 0.06) |
0.12 (0.03; 0.21) p= 0.0078 0.14 (-0.00; 0.29) p= 0.0556 0.11 (-0.00; 0.23) p= 0.0577 |
| Normal, n (%) | 77 (66%) | 78 (67%) | |
| Osteopenia, n (%) | 31 (26%) | 32 (28%) | |
| Osteoporosis, n (%) | 9 (8%) | 6 (5%) |
T - and Z-scores as means with 95% CI (). Glu: Glucocorticoid treatment.
Conclusion: BMD increased over 12 months without association with glucocorticoid treatment. For columna the increase was associated with male gender and bisphosphonate treatment.