ERS Respiratory Channel

CDN Connection Issue

It appears that your current network does not allow connection to the CDN (Content Delivery Network) required for this service to function properly.

To resolve this issue, please try the following actions :

• Contact your network administrator : Inform them of this restriction so they can adjust the network settings accordingly.

• Use another network : Try connecting from a different network, such as another Wi-Fi network or a mobile connection.

We apologize for the inconvenience and thank you for your understanding.

Abstract

Aims

Subclinical heart failure may lead to congestion in the pulmonary veins and increased mortality. Aim: To determine the association of pulmonary vein volume with all-cause mortality in smokers with and without COPD.

Methods

The artery-vein phenotyping analysis (AVX) was performed using the AI-based lung quantification platform LungQ (Thirona, The Netherlands). AVX quantified total volume of small (diameter <2mm; AVX_SV) and large (?2mm; AVX_LV) pulmonary veins on CT in 7903 participants of the COPDGene study, normalized for body height. Cox regression analysis was used to analyze associations between AVX_SV and AVX_LV scores and mortality. Corrections were made for age, sex, BMI, FEV1%predicted, mMRC, 6MWT, smoking status, emphysema, airway wall thickness, coronary artery calcium score, severe exacerbations, and scanner model.

Results

Mean age was 60.1±9.0 years; 3594 (45.5%) subjects had COPD. AVX_SV was 82.3±13.3 mm3/cm; AVX_LV 178.2±53.1 mm3/cm. Higher AVX_SV and AVX_LV were both associated with higher mortality, HR 1.57 (CI 1.31-1.88) and HR 1.07 (CI 1.01-1.13) per 50 mm3/cm, respectively.

Conclusions

Increased pulmonary venous volume is associated with a higher mortality in smokers with and without COPD, independent of emphysema and coronary artery calcium score, and may be a marker of volume redistribution as a result of heart failure.

Abstract

#{title}