The aim of the UPHILL study was to determine the effect of an innovative nutritional intervention on adjustments in nutritional intake and quality of life(QoL) in patients with pulmonary arterial hypertension(PAH). In this study a group of prevalent PAH patients at a single center in Amsterdam was informed about healthy nutrition using a newly designed video e-learning. Nutritional intake was assessed using a food frequency questionnaire(HELIUS) and QoL by the Short-Form(SF)-36 questionnaire. Nutritional parameters were determined in  blood samples. 17 patients stable under treatment, who had been diagnosed with PAH 7.0 [3.0, 14.0] years before, started and completed the intervention (2 males, 15 females; 45 ± 14 years). Despite the fact that patients had already high mean QoL scores at baseline, scores improved further during e-learning. Furthermore, patients who realized most nutritional adaptations, had the best improvement in QoL. This proof of principle study showed that e-learning modules on nutrition provide an unique opportunity to change nutritional intake in PAH patients and by that improve QoL.