Background Psychosocial impacts of lung cancer screening remain unclear. Few studies used condition-specific questionnaires.

Aim To describe short-term psychosocial impacts of screening among an Australian high-risk cohort participating in lung cancer screening using a condition-specific questionnaire.

Method Australian ILST (NCT02871856) participants were invited to this study. The Danish Consequences Of Screening Lung Cancer (COS-LC) questionnaire is a valid condition-specific questionnaire which has been translated and validated in our Australian ILST cohort. COS-LC was administered before screening, one month after baseline results, and at intervals dependent on ILST protocols. Participants were split according to LDCT category (CAT1=normal findings, CAT2=low malignancy risk, CAT3=moderate malignancy risk, CAT4=high malignancy risk, and CAT5=suspicious for lung cancer). We present pre-screening and post baseline LDCT results.

Results 1129 participants had a median age of 63; 80% were male. CAT1, CAT2, CAT3, CAT4, and CAT5 comprised of 79%, 12%, 6%, 1%, and 2% of the cohort respectively. There was no significant difference in mean score between groups pre-screening. After baseline results, there was no statistically significant difference in change between the CAT mean scores, other the ?empathy? scale. CAT3-5 had an increase, suggesting increased impact on empathy for others, whereas CAT2 had a decrease (CAT1 reference).

Conclusion Early results demonstrate no significant difference in psychosocial impacts between ISLT category groups in the period immediately following the screening. CAT4 and CAT5 groups had limited numbers.