Introduction:The SARS-CoV2 has been circulating in population worldwide for more than 2 years.The crucial mechanisms of cardiac injury,during COVI19,are not clearly understood.It has been suggested that they are most likely multifactorial:direct cardiotoxicity and indirect caused by capillary endothelial dysfunction.We aimed to investigate the link between endothelial dysfunction and left ventricular global strain (LVGS).

Materials and methods:A prospective multicenter study, including young patients without any comorbidity and with a history of COVID19 infection.A healthy control group matched for age, gender and BMI to the COVID 19 group was included. An echocardiography and a capillaroscopy are performed in all subjects at inclusion and after one month.

Results:A total of 158 patients were included: 80 patients with a confirmed COVID19 diagnosis and 78 persons as a healthy control group. The mean age of the study population was 35±7.7 years and 85.7% were female.

The comparison between the 2 groups revealed no statistically significant difference in terms of LVEF,E wave,A wave and TAPSE.The LVGS values of the control and COVID19 patients were -19.6±1.6 and -18.2±2.4, (p=0.001).

In the group of patient with COVID19 infection, 45 patients (56.3%) had an impaired LVGS and 23 patients (28.7%) had an endothelial dysfunction with the mean EQI was 2.4±0.9. There was a negative correlation between LVGS and EQI(r=-0.34, p=0.002). At one month follow-up, there was an improvement of the EQI and the LVGS, with p=0.012 and p=0.001.

Conclusion:There is an increasing evidence of a strong link between the endothelial function and the value of LVGS in COVID19.