PDE4B inhibitor BI1015550 improves lung fibrosis, modulates transcriptome in bleomycin-treated rats, and attenuates fibrotic markers in human lung fibroblasts and epithelial cells - Milan 2023

Cutting-edge approaches to model and treat lung disease

Chair(s): Mareike Lehmann, Thomas Wilkinson

Session type: Poster session

PDE4B inhibitor BI1015550 improves lung fibrosis, modulates transcriptome in bleomycin-treated rats, and attenuates fibrotic markers in human lung fibroblasts and epithelial cells

Dennis Reininger

EVENTS HOME

Poster
Abstract

Previous presentation

Next presentation

Session content

Development of a high throughput primary human fibroblast-to-myofibroblast transition assay

Elisabeth Back

Poster

Abstract

Targeting deubiquitinases for the treatment of COPD

Amy Hendren

Poster

Abstract

Early immune development in the human fetal lung

L. Jia

Poster

Abstract

Development of a huPCLS platform to explore IL-33 biology and test novel therapies

Josquin Nys

Poster

Abstract

Rat-to-human translation of an antigen-specific, CD4+ T-cell-induced model of airway myocyte hyperplasic remodeling

David Ramos Barbon

Poster

Abstract

Development of a Xenopus-based assay for high-throughput evaluation of mucociliary flow

Panayiotis Kouis

Poster

Abstract

Investigating miRNA regulation of PTEN in Cystic Fibrosis using airway epithelial cells derived from patient specific iPSC

Irene Oglesby

Poster

Abstract

Establishing the Conditionally Reprogrammed Cell Technology for precision medicine in PCD

Ruth Urbantat

Poster

Abstract

Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

Lisa Douglas

Poster

Abstract

Tridimentional microscopy unravels distal architecture of IPF

Youri Bertrand

Poster

Abstract

Characterisation of airway epithelial cells from survivors of very preterm birth reveal barrier defects at one year of age.

Denby Evans

Poster

Abstract

MicroRNA transfection of 3D lung tissue model is possible

Joanna Nowakowska

Poster

Abstract

Additional effects of oral prednisolone following mepolizumab on the nasal transcriptome

Imran Howell

Poster

Abstract

IL-6 trans-signaling implicated in bronchial epithelial SERPIN B3/B4 mediated fibrogenesis and epithelial disruption in severe asthma

Chih-chieh Tseng

Poster

Abstract

Proteomic profiling of air-liquid-interface (ALI)-cultured primary ciliary dyskinesia (PCD) nasal epithelia

Katie L Horton

Poster

Abstract

PDE4B inhibitor BI1015550 improves lung fibrosis, modulates transcriptome in bleomycin-treated rats, and attenuates fibrotic markers in human lung fibroblasts and epithelial cells

Dennis Reininger

Poster

Abstract

Single-cell RNA sequencing reveals defective bronchial epithelial cell differentiation in patients with severe COPD in 3-dimensional organoid cultures

Kingsley Okechukwu Nwozor

Poster

Abstract

CDN Connection Issue

The ERS International Congress 2023, Milan

#{title}