PDE4B inhibitor BI1015550 improves lung fibrosis, modulates transcriptome in bleomycin-treated rats, and attenuates fibrotic markers in human lung fibroblasts and epithelial cells

Cutting-edge approaches to model and treat lung disease

Chair(s): Mareike Lehmann, Thomas Wilkinson

Session type: Poster session

Dennis Reininger

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Development of a high throughput primary human fibroblast-to-myofibroblast transition assay

Elisabeth Back

Poster

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Targeting deubiquitinases for the treatment of COPD

Amy Hendren

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Early immune development in the human fetal lung

L. Jia

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Development of a huPCLS platform to explore IL-33 biology and test novel therapies

Josquin Nys

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Rat-to-human translation of an antigen-specific, CD4+ T-cell-induced model of airway myocyte hyperplasic remodeling

David Ramos Barbon

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Development of a Xenopus-based assay for high-throughput evaluation of mucociliary flow

Panayiotis Kouis

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Investigating miRNA regulation of PTEN in Cystic Fibrosis using airway epithelial cells derived from patient specific iPSC

Irene Oglesby

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Establishing the Conditionally Reprogrammed Cell Technology for precision medicine in PCD

Ruth Urbantat

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Highly selective furin inhibition as a therapeutic approach for chronic obstructive pulmonary disease

Lisa Douglas

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Tridimentional microscopy unravels distal architecture of IPF

Youri Bertrand

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Characterisation of airway epithelial cells from survivors of very preterm birth reveal barrier defects at one year of age.

Denby Evans

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MicroRNA transfection of 3D lung tissue model is possible

Joanna Nowakowska

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Additional effects of oral prednisolone following mepolizumab on the nasal transcriptome

Imran Howell

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IL-6 trans-signaling implicated in bronchial epithelial SERPIN B3/B4 mediated fibrogenesis and epithelial disruption in severe asthma

Chih-chieh Tseng

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Proteomic profiling of air-liquid-interface (ALI)-cultured primary ciliary dyskinesia (PCD) nasal epithelia

Katie L Horton

Poster

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PDE4B inhibitor BI1015550 improves lung fibrosis, modulates transcriptome in bleomycin-treated rats, and attenuates fibrotic markers in human lung fibroblasts and epithelial cells

Dennis Reininger

Poster

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Single-cell RNA sequencing reveals defective bronchial epithelial cell differentiation in patients with severe COPD in 3-dimensional organoid cultures

Kingsley Okechukwu Nwozor

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The ERS International Congress 2023, Milan

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