mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis. - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 1

Chair(s): Corry-Anke Brandsma, Katherine Landwehr, Åsa Wheelock, Amy Wong, Charikleia Ntenti, Cengiz Goekeri, Martijn C. Nawijn

Session type: Poster Session

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

Roya Babaei Jadidi

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Optimization of single-nucleus RNA sequencing for superior characterization of the airway wall cellular landscape in pulmonary disease

Sjors Maassen

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Developing a novel method for visualizing cell-directed extracellular matrix remodelling for investigating lung regeneration mechanisms

Isidora Kraguljac

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Cheng-yu Wu

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Ahmed Agami

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Alveolar type 2 cell senescence is a critical mechanism involved in the lack of repair during emphysema

Perla Abou Atmeh

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3D-Bioprinting of induced pluripotent stem cell-derived alveolar epithelial type 2 cells (iAT2) spheroids.

Cormac Murphy

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Critical role for the TGF-?1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts in IPF

Manuela Platé

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TGF? induces changes indicative of neuroplasticity in a novel model of hPSC-derived sensory neurons.

Carli Koster

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Reversing Bleomycin-Induced Lung Fibrosis through targeted MicroRNA inhibition: An ATII-driven therapeutical Approach for Alveolar Repair in IPF

Giulia Zandomenego

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Dissecting immunoproteasome function in lung regeneration using mouse lung organoid

Kai Guo

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Benefits of bronchial epithelial repair by iPSCs in COPD

Marion Nadaud

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FAP+ fibroblasts differentially directs stromal-immune signaling in healthy and diseased lungs

Jelmer Vlasma

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Assessing therapeutic versus prophylactic efficacy of mesenchymal stem cells in LPS-induced lung injury model using BALB/c mice

Mogesh Sababathy

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Quantitative Assessment of Pulmonary Extracellular Matrix Remodelling as a Platform to Enable Regenerative Lung Interventions

Thomas Wilkinson

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Tracing the origin of RSMCs in airway epithelial regeneration

Mahtab Shahriari Felordi

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Lipid mediators control macrophage and fibroblast phenotype, and support regeneration in the alveolar niche

Melker Göransson

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Lipid hydrolysis fuels alveolar type 2 cell-mediated lung regeneration

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Investigating the Lipofibroblasts in post-ARDS regeneration

Georgios Kiliaris

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Role of CFTR in airway epithelial differentiation and regeneration

Ines Pankonien

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MMP14-generated endostatin drives vascular remodeling via Notch3 activation in idiopathic pulmonary arterial hypertension

Johannes Lorenz Berg

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The dual impact of TNF? on lung regeneration: divergent effects on epithelial cells and fibroblasts

Rocío Fuentes-mateos

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A novel model of short telomere related pulmonary fibrosis using alveolar epithelial type 2 cells generated from patient-derived induced pluripotent stem cells

Mari Ozaki

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Cell culture differentiation and proliferation conditions influence the in vitro regeneration of the human airway epithelium

Laure-emmanuelle Zaragosi

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Anti-fibrotic effects on extracellular matrix remodeling ex vivo: Insights from human lung slices and extended microphysiological system culture

Lena Willmer

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Investigating the mechanisms through which lung MSCs regulate endothelial functionality in COPD using distal lung organoid models

Mark Bell

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Cell-intrinsic mechanisms of lung regeneration and resilience over the lifespan

Gowtham Kumar Boosarpu Gopinath

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Abstract

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

Roya Babaei Jadidi

Poster

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Therapeutic strategies to favor epithelial repair and regeneration in preclinical models of primary airway and alveolar cultures and live lung tissue

Emmanuelle Brochiero

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Rejuvenation of airway basal stem cells by partial chemical reprogramming Mengyu Zou1, Qiaoyu Chen1, Ying Hua1, Wei Zuo1,2* 1Tongji Stem Cell Center, Tongji University, Shanghai, China 2Kiangnan Institute of Stem Cell, Hangzhou, China

Wei Zuo

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N23Ps as a novel antifibrotic therapy: insights from 3D human fibrosis model and single-cell profiling

Diana L Porras Gonzalez

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CDN Connection Issue

Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

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