Chair: Dr Hitasha Rupani (Southampton, United Kingdom)
Speakers: Dr Israel Silva Maia (Florianópolis (SC), Brazil), Dr Georgios Mavrovounis (larisa, Greece), Dr Mathieu Marillier (Echirolles, France), Dr Augusta Beech (Manchester, United Kingdom)

Fees: Free for ERS members / €10 for non-members
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Overview

The choice between high-flow nasal oxygen (HFNO) and noninvasive ventilation (NIV) in acute respiratory failure (ARF) and COPD exacerbations remains a key clinical challenge. While NIV has been a standard of care, HFNO has emerged as an alternative in certain patient populations, with ongoing debate about its effectiveness and optimal use.

Healthcare professionals face several knowledge gaps in this area, including:

• Understanding when HFNO can replace or complement NIV in ARF and COPD exacerbations.

• Evaluating the latest clinical trial evidence comparing these modalities.

• Applying individualised strategies for selecting the most appropriate noninvasive support.

Aims and Topics:

This journal club webinar will critically examine these issues by featuring two recent high-impact studies:

1. Israel Maia will present findings from the RENOVATE trial, which evaluates HFNO vs. NIV in acute respiratory failure. Access the article.
   
2. Georgios Mavrovounis will discuss his randomised noninferiority trial, which investigates HFNO vs. NIV in hypercapnic COPD exacerbations. Access the article.

Each study will be presented in a 15-20 minute session, followed by a cross-analysis discussion with Mathieu Marillier and Augusta Beech, who will provide expert insights on the comparative findings and clinical implications. A dedicated Q&A session will allow for interactive engagement with the speakers and panelists.

Through this structured discussion, participants will gain the necessary knowledge to optimise respiratory support strategies and improve patient outcomes.

Format and Structure:

1. Introduction by the Chairperson (5 minutes)
- Overview of the theme, objectives, and speakers

2. Presentation 1: Israel Maia (15-20 minutes)
- Study: RENOVATE trial (HFNO vs. NIV in acute respiratory failure).
- Focus: Comparative effectiveness, patient outcomes, and key takeaways.

3. Presentation 2: Georgios Mavrovounis (15-20 minutes)
- Study: Randomised noninferiority trial (HFNO vs. NIV in hypercapnic COPD exacerbations).
- Focus: Efficacy of HFNO, patient selection, and clinical impact.

4. Cross-analysis and comparative discussion (10 minutes)
- Moderated by Hitasha Rupani, Mathieu Marillier and Augusta Beech asking questions, with key discussion points including:
- Similarities and differences in study design and findings.
- Clinical scenarios where HFNO may replace or complement NIV.
- Practical application in emergency and intensive care settings.
- Contributions from invited experts

5. Interactive Q&A session (10-15 minutes)
- Open floor for participant questions.

6. Closing Remarks (5 minutes)
- Summary of key takeaways.
- Final insights from speakers and moderators.

Learning outcomes

Following this webinar, participants will be able to:

1. Compare the effectiveness of HFNO vs. NIV in managing acute respiratory failure and COPD exacerbations.
2. Analyse the key findings from the RENOVATE trial and the noninferiority study in COPD.
3. Identify patient populations that may benefit from HFNO as an alternative to NIV.
4. Apply evidence-based strategies to optimise noninvasive respiratory support in clinical practice.

CME credit

An application for accreditation of this webinar has been made to the European Board for Accreditation in Pneumology (EBAP) for 1 CME credit per 1-hour attendance. If accredited, the CME credit will be granted upon attendance of at least 60 minutes during the live webinar only.

What is a webinar?

A webinar closely simulates a lecture-based teaching experience. The speaker can interact with the audience, just as in a classroom setting. During the webinar, you will be asked to share your opinion on issues related to the topic using interactive polls.

All participants will be able to hear the lecturer and see the slides throughout the presentation. As a participant you will be able to pose questions or discuss ideas with the other participants via the text chat facility and the speaker will respond to the questions via the microphone.