Imatinib treatment for fibrotic lung disorders: ex vivo assessment on human lungs.

Basic mechanism and novel treatment targets in pulmonary fibrosis

Chair(s): ARGYRIS TZOUVELEKIS, Vanesa Vicens Zygmunt

Session type: Poster session

Sara Bozzini

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A multicenter study of extracellular vesicles profile in bronchoalveolar lavage from patients affected by IPF, HP and sarcoidosis

Miriana D'alessandro

Poster

Abstract

Iron status and the risk of idiopathic pulmonary fibrosis: a mendelian randomization study

Jian Zhou

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Microcomputed tomography to study the in vivo development of IPF-like disease in conditional Nedd4-2 deficient mice

Dominik Leitz

Poster

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CycloZ reduces inflammation in bleomycin-induced idiopathic pulmonary fibrosis model mice.

Seoyeong Baek

Poster

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Regenerative capacity of alveolar type 2 cells is proportionally reduced following disease progression in IPF-derived organoid cultures

Hyeon Kyu Choi

Abstract

Hyaluronic acid decorated-liposome loaded with Imatinib (XHALIP): delivered intratracheally are effective in a Bleomycin model of lung fibrosis

Federica Meloni

Poster

Abstract

Imatinib treatment for fibrotic lung disorders: ex vivo assessment on human lungs.

Sara Bozzini

Poster

Abstract

Fcor/FOXO1 axis regulates GLUT1-mediated mitochondrial oxidative stress and metabolic reprogramming in angiotensin II-induced fibroblast activation

Wei Wang

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Intratracheal administration of a PROTAC with subnanomolar potency induces BRD4 degradation in the lung without systemic target engagement

Ulf Hedstrom

Poster

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Novel waveform analysis reveals persistent pathophysiological changes in rodent model of pulmonary fibrosis

Maria Volovaya

Poster

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Data-driven processing of electronic medical record (EMR) and serum exosome proteomics data of idiopathic pulmonary fibrosis (IPF) patients identified pathological networks and its regulatory molecules

Mari Nogami-itoh

Poster

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CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome.

Dohyun Lee

Poster

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A clinical-stage RNAi therapeutic candidate for IPF mediates durable MMP7 silencing in nonhuman primates and human lung tissue

Tingting Yuan

Poster

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Abnormal phosphorylation of Per2 induces myofibroblast transformation and promotes the development of pulmonary fibrosis

Mei Chen

Abstract

Use of invasive lung function assessment (DSI/Buxco) to quanity changes in lung function parameters in a rat bleomycin model of lung fibrosis.

Mary Mcelroy

Abstract

Impact of Bifidobacterium longum BB536 on nausea caused by pirfenidone in a mouse model of pellagra

Koji Kuronuma

Poster

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Bleomycin does not directly cause fibrosis in precision-cut lung slices, PCLS

Satoshi Kanazawa

Poster

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Preclinical evaluation of Ezetimibe for repurposing to pulmonary fibrosis.

Chanho Lee

Poster

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A novel senolytic drug, ARV-825, ameliorates experimental lung fibrosis

Seidai Sato

Poster

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Aging disturbed lysosomes to modulate efferocytosis-induced SPP1-expressing macrophage and inhibit pulmonary fibrosis reversal

Yue Zhang

Poster

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The ERS International Congress 2023, Milan

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