Preclinical evaluation of HL001, a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, for idiopathic pulmonary fibrosis utilizing physiologically relevant stem cell-derived lung organoids

From the transcriptome landscape to innovative preclinical models in lung diseases

Chair(s): Sara Cuevas Ocana, Arnaud Mailleux

Session type: Oral presentation

Yuki Yamamoto

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Late Breaking Abstract - Development of a bronchial epithelium with a sensory innervation both derived from induced pluripotent stem cells

Arnaud Bourdin

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Late Breaking Abstract - Volatile organic compounds in exhaled breath reflect physiological changes in ultramarathon runners

Agnieszka Smolinska

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Identification of abnormal airway niches in the fibrotic lung using Spatial Transcriptomics

Aurelien Justet

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Single-cell RNA sequencing of bronchoalveolar lavage reveals pro-inflammatory macrophage activation in fibrotic hypersensitivity pneumonitis

Avraham Unterman

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Transcriptomic landscape of post-covid-19 pulmonary fibrosis (PCPF): insights and implications of bronchoalveolar lavage (BAL)

Mohammad Shadab Ali

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LSC - 2023 - In vitro modelling of respiratory infections in Idiopathic Pulmonary Fibrosis using patient-specific hiPSC-derived alveolar epithelial cells

Serna Valverde Ana Lilia

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Preclinical evaluation of HL001, a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, for idiopathic pulmonary fibrosis utilizing physiologically relevant stem cell-derived lung organoids

Yuki Yamamoto

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Dual ?V?6/?V?1 integrin inhibitor bexotegrast reduces fibrogenesis in pathological cell populations present in the fibrotic human lung

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Involvement of the CXCR4/CXCL12 axis in skeletal muscle wasting in a murine model of Chronic Obstructive Pulmonary Disease (COPD)

Pauline Henrot

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Discussion and Q&A

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The ERS International Congress 2023, Milan

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