Fcor/FOXO1 axis regulates GLUT1-mediated mitochondrial oxidative stress and metabolic reprogramming in angiotensin II-induced fibroblast activation - Milan 2023

Basic mechanism and novel treatment targets in pulmonary fibrosis

Chair(s): ARGYRIS TZOUVELEKIS, Vanesa Vicens Zygmunt

Session type: Poster session

Fcor/FOXO1 axis regulates GLUT1-mediated mitochondrial oxidative stress and metabolic reprogramming in angiotensin II-induced fibroblast activation

Wei Wang

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Abstract

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Sara Bozzini

Poster

Abstract

Fcor/FOXO1 axis regulates GLUT1-mediated mitochondrial oxidative stress and metabolic reprogramming in angiotensin II-induced fibroblast activation

Wei Wang

Abstract

Intratracheal administration of a PROTAC with subnanomolar potency induces BRD4 degradation in the lung without systemic target engagement

Ulf Hedstrom

Poster

Abstract

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Maria Volovaya

Poster

Abstract

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Mari Nogami-itoh

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Abstract

CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome.

Dohyun Lee

Poster

Abstract

A clinical-stage RNAi therapeutic candidate for IPF mediates durable MMP7 silencing in nonhuman primates and human lung tissue

Tingting Yuan

Poster

Abstract

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Mei Chen

Abstract

Use of invasive lung function assessment (DSI/Buxco) to quanity changes in lung function parameters in a rat bleomycin model of lung fibrosis.

Mary Mcelroy

Abstract

Impact of Bifidobacterium longum BB536 on nausea caused by pirfenidone in a mouse model of pellagra

Koji Kuronuma

Poster

Abstract

Bleomycin does not directly cause fibrosis in precision-cut lung slices, PCLS

Satoshi Kanazawa

Poster

Abstract

Preclinical evaluation of Ezetimibe for repurposing to pulmonary fibrosis.

Chanho Lee

Poster

Abstract

A novel senolytic drug, ARV-825, ameliorates experimental lung fibrosis

Seidai Sato

Poster

Abstract

Aging disturbed lysosomes to modulate efferocytosis-induced SPP1-expressing macrophage and inhibit pulmonary fibrosis reversal

Yue Zhang

Poster

Abstract

CDN Connection Issue

The ERS International Congress 2023, Milan

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