Chair(s): Marc Humbert, Vallerie V. McLaughlin, Gabor Kovacs
Session type: Hot topics
Ioana R Preston
Session content
Paul Yu
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Slides
Germline mutations of genes encoding for the TGF-beta superfamily in pulmonary arterial hypertension
Christina A. Eichstaedt
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Slides
Laurent Savale
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Slides
Targeting TGF-beta superfamily in pulmonary arterial hypertension
Ioana R Preston
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Slides
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Session aims
To explain the transforming growth factor (TGF)-?/bone morphogenetic protein proliferative/apoptotic signalling pathway in pulmonary arterial hypertension (PAH); to describe the current drug development stage including the different monoclonal antibodies targeting the TGF-? signalling pathway; to demonstrate the use of molecules belonging to the TGF-? signalling pathway as prognostic biomarkers in PAH; to present the results of recent clinical trials using monoclonal antibodies targeting TGF-? signalling in PAH and the future treatment algorithm using monoclonal antibodies.