Identification of epithelial properties driving airway remodeling in severe asthma - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 2

Chair(s): Niki L. Reynaert, Peter Pennitz, Mogesh Sababathy, Perla Abou atmeh, Carsten Schmidt-Weber, Ken Bracke, Ahmed Agami

Session type: Poster Session

Identification of epithelial properties driving airway remodeling in severe asthma

Laure-emmanuelle Zaragosi

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Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

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Targeting the Fibrotic Phase of Diffuse Alveolar Damage: Early Pathways for Post-COVID-19 pulmonary fibrosis

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Development of novel therapeutics against idiopathic pulmonary fibrosis with potent antifibrotic effects and unique mode of action.

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In-vitro analysis of cellular bioenergetics reveal a reduced mitochondrial spare respiratory capacity in bronchial epithelial cells of COPD patients

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Defining the Prototype of Immune Cell Driven Fibrotic Tissue Organization in Restrictive Allograft Syndrome and Pleuroparenchymal Fibroelastosis

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Lineage tracing reveals the fate of lung endothelial cells in the progression of pulmonary fibrosis

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Baddini-Capelozzi’s Necrosis

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Iron-loaded alveolar macrophages alter alveolar type 2 epithelial cell function in COPD

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Counteracting pulmonary vascular endothelial cell senescence to combat age-related lung dysfunction and pulmonary hypertension

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In Vitro Microfluidic Breathomics: epithelial volatiles and whole patient breath in COPD

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Bleomycin induces long-lasting fibrosis in premature aging ERCC1?/- mice.

Zahra Khalajzeyqami

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Female sex hormones change the antiviral response of the bronchial epithelium in women with severe asthma

Cornelia Blume

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Extracellular vesicles with HSP90 promote pulmonary fibrosis.

Léo Biziorek

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Oxidative and nitrosative stress in pulmonary vessels contribute to vascular remodelling and emphysema development in COPD

Stefan Hadzic

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Increased P2 purinergic signalling in circulating monocytes of patients with progressive pulmonary fibrosis

Luke Forde

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Identification of genetic modifying factors of lung disease in PI*ZZ Alpha-1 Antitrypsin Deficiency and their role in alveolar cells

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Pulmonary glycosaminoglycans and fucosylation regulate lung barrier function and defense against S.pneumoniae

Cengiz Goekeri

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Role of Ferroptosis in the interplay between metabolically distinct macrophages and lungs cells in the context of Idiopathic Pulmonary Fibrosis

Julia Sauer

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Elucidating the Mechanobiology of COPD Fibroblasts: The Role of Yes-Associated Protein (YAP)

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Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion

Dustin Bagley

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The role of ferroptosis and its inhibition in COPD

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Exploring the antifibrotic potential of the heparan sulfate mimetic OTR4120

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Divergent roles of senescent endothelial cells in the development of pulmonary arterial hypertension

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Desmoplakin loss induces Wnt/?-catenin-dependent fibrotic gene expression and promotes pulmonary fibrosis development

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The bacterial lysate OM-85 mitigates HDM-induced allergic inflammation through airway epithelial cell- macrophage crosstalk

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Bronchial transcriptomics identifies distinct endotypes of severe COPD

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Development of a chronic in vitro fibrotic model to investigate the role of DDR1 and DDR2 in lung fibrogenesis.

Annabel Kunzemann Martinez

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Sex hormones modulate the onset of pulmonary fibrosis in type 2 alveolar epithelial cells

Anja Schweikert

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Imaging mass cytometric analysis of human fetal lung development reveals close interactions between epithelial and immune cells.

Padmini P. S. J. Khedoe

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Female-specific biological aging is associated with asthma.

Karosham Reddy

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TCF21 Deficiency Induces Fibroblast Apoptosis and Promotes Fibrotic Changes in the Human Lung Mesenchyme

Stephanie T. Pohl

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Peptidyl-arginine deiminases as bactericidal and anti-biofilm agents against Pseudomonas aeruginosa

Rory Baird

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Identification of epithelial properties driving airway remodeling in severe asthma

Laure-emmanuelle Zaragosi

Poster

Abstract

MEOX2-mediated epigenetic remodelling of lung epithelial cells in COPD and lung malignancy

Priscila Pineda Villegas

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Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

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