Counteracting pulmonary vascular endothelial cell senescence to combat age-related lung dysfunction and pulmonary hypertension - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 2

Chair(s): Niki L. Reynaert, Peter Pennitz, Mogesh Sababathy, Perla Abou atmeh, Carsten Schmidt-Weber, Ken Bracke, Ahmed Agami

Session type: Poster Session

Counteracting pulmonary vascular endothelial cell senescence to combat age-related lung dysfunction and pulmonary hypertension

Juliette Jacquet

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Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

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Targeting the Fibrotic Phase of Diffuse Alveolar Damage: Early Pathways for Post-COVID-19 pulmonary fibrosis

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Development of novel therapeutics against idiopathic pulmonary fibrosis with potent antifibrotic effects and unique mode of action.

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In-vitro analysis of cellular bioenergetics reveal a reduced mitochondrial spare respiratory capacity in bronchial epithelial cells of COPD patients

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Defining the Prototype of Immune Cell Driven Fibrotic Tissue Organization in Restrictive Allograft Syndrome and Pleuroparenchymal Fibroelastosis

Lena Maureen Leiber

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Lineage tracing reveals the fate of lung endothelial cells in the progression of pulmonary fibrosis

Elisabeth Fließer

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Baddini-Capelozzi’s Necrosis

Alexandre Todorovic Fabro

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Iron-loaded alveolar macrophages alter alveolar type 2 epithelial cell function in COPD

Sophia Wugk

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Counteracting pulmonary vascular endothelial cell senescence to combat age-related lung dysfunction and pulmonary hypertension

Juliette Jacquet

Poster

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In Vitro Microfluidic Breathomics: epithelial volatiles and whole patient breath in COPD

Brady Rae

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Bleomycin induces long-lasting fibrosis in premature aging ERCC1?/- mice.

Zahra Khalajzeyqami

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Female sex hormones change the antiviral response of the bronchial epithelium in women with severe asthma

Cornelia Blume

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Extracellular vesicles with HSP90 promote pulmonary fibrosis.

Léo Biziorek

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Oxidative and nitrosative stress in pulmonary vessels contribute to vascular remodelling and emphysema development in COPD

Stefan Hadzic

Poster

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Increased P2 purinergic signalling in circulating monocytes of patients with progressive pulmonary fibrosis

Luke Forde

Poster

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Identification of genetic modifying factors of lung disease in PI*ZZ Alpha-1 Antitrypsin Deficiency and their role in alveolar cells

Nerea Matamala

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Pulmonary glycosaminoglycans and fucosylation regulate lung barrier function and defense against S.pneumoniae

Cengiz Goekeri

Poster

Abstract

Role of Ferroptosis in the interplay between metabolically distinct macrophages and lungs cells in the context of Idiopathic Pulmonary Fibrosis

Julia Sauer

Poster

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Elucidating the Mechanobiology of COPD Fibroblasts: The Role of Yes-Associated Protein (YAP)

Bryan Falcones Olarte

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Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion

Dustin Bagley

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The role of ferroptosis and its inhibition in COPD

Silke Geirnaert

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Exploring the antifibrotic potential of the heparan sulfate mimetic OTR4120

Manuela Marega

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Divergent roles of senescent endothelial cells in the development of pulmonary arterial hypertension

Elmira Safaie Qamsari

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Desmoplakin loss induces Wnt/?-catenin-dependent fibrotic gene expression and promotes pulmonary fibrosis development

Pooja Singh

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The bacterial lysate OM-85 mitigates HDM-induced allergic inflammation through airway epithelial cell- macrophage crosstalk

Athanasios Kouklas

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Bronchial transcriptomics identifies distinct endotypes of severe COPD

Maidinuer Saimi

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Development of a chronic in vitro fibrotic model to investigate the role of DDR1 and DDR2 in lung fibrogenesis.

Annabel Kunzemann Martinez

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Sex hormones modulate the onset of pulmonary fibrosis in type 2 alveolar epithelial cells

Anja Schweikert

Poster

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Imaging mass cytometric analysis of human fetal lung development reveals close interactions between epithelial and immune cells.

Padmini P. S. J. Khedoe

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Female-specific biological aging is associated with asthma.

Karosham Reddy

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TCF21 Deficiency Induces Fibroblast Apoptosis and Promotes Fibrotic Changes in the Human Lung Mesenchyme

Stephanie T. Pohl

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Peptidyl-arginine deiminases as bactericidal and anti-biofilm agents against Pseudomonas aeruginosa

Rory Baird

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Identification of epithelial properties driving airway remodeling in severe asthma

Laure-emmanuelle Zaragosi

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MEOX2-mediated epigenetic remodelling of lung epithelial cells in COPD and lung malignancy

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Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

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