Chair: Dr Marlieke de Kraker (Geneva, Switzerland)

Speakers: Dr Peter van de Ven (Utrecht, Netherlands), Dr Sofia Villar (Cambridge, United Kingdom), Dr David Paterson (Singapore)

Fees: Free for ERS members and non-members
Find out more about becoming a member

Overview

Infectious diseases are an important global concern, but traditional randomised controlled trials lag behind what is needed in terms of rapid development of diagnostics, vaccines, and treatments. In particular, fixed trial designs cannot adapt to rapidly evolving research findings and treatments, hindering their utility in the context of an emerging pathogen.

In contrast, adaptive trial designs offer a compelling alternative where trial parameters can be modified during the trial, based on pre-specified rules, to respond to emerging research findings.

The ECRAID Training modules on adaptive clinical trial designs introduced several different types of adaptive designs and discussed their advantages and limitations. This webinar will bring the online modules to a close, by having experts in the field discuss the process of choosing an adaptive trial design for a specific respiratory infection example. Several variations will be explored, and the most suitable adaptive design will be discussed for each.

Topics:

• Adaptive clinical trial designs (including: seamless trials, group sequential design, sample size re-estimation, response adaptive randomisation and platform trials) in the setting of a respiratory infection.

Format

One-hour webinar format: 45 minutes for presentation, followed by a 15-minute Q&A session.

Learning outcomes

Following this webinar, participants will be able to:

• Describe the most relevant types of adaptive trial designs.
• Explain the advantages and disadvantages of different types of adaptive trial designs.
• Understand the process of how to choose the most suitable clinical trial design.

CME credit

An application for accreditation of this webinar has been made to the European Board for Accreditation in Pneumology (EBAP) for 1 CME credit per 1-hour attendance. If accredited, the CME credit will be granted upon attendance of at least 60 minutes during the live webinar only.

What is a webinar?

A webinar closely simulates a lecture-based teaching experience. The speaker can interact with the audience, just as in a classroom setting. During the webinar, you will be asked to share your opinion on issues related to the topic using interactive polls.

All participants will be able to hear the lecturer and see the slides throughout the presentation. As a participant you will be able to pose questions or discuss ideas with the other participants via the text chat facility and the speaker will respond to the questions via the microphone.

Login guidelines

More information will be communicated in due course.

• Please log in to the webinar 20 minutes before it is scheduled to commence. If you have any technical difficulties whilst trying to log in or during the session please contact e-learning@ersnet.org.
• Check Central European Time.
• To achieve the best quality, we recommend to avoid downloading anything from the internet during your connection to the lecture and stopping all other programmes.
• Please also ensure that your audio settings are not set to mute and adjust the volume to a comfortable level.

About Ecraid

The European Clinical Research Alliance for Infectious Diseases (Ecraid) is a non-profit organisation that advances clinical research in the field of infectious diseases through international collaboration. Headquartered in Utrecht, the Netherlands, Ecraid offers a single point of access to key academic opinion leaders and Europe's largest academic clinical research network for infectious diseases. For more information, visit www.ecraid.eu.

The ECRAID-Base project is funded by Horizon 2020 through the Grant Agreement n° 965313.