Chair(s): Silke Meiners, Didier Cataldo
Session type: Symposium
Miguel Angel Alejandre Alcázar
Session content
Cecilie Svanes
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From the uterus to lung disease: intergenerational triggers of premature lung inflammaging
Miguel Angel Alejandre Alcázar
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Morten Scheibye-knudsen
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Mareike Lehmann
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Session aims
to present accelerated lung ageing and the risk of chronic lung disease across the entire lifespan, ranging from the intrauterine/perinatal and preconception period to ageing humans; to address the following knowledge gaps: when does ageing begin, how does inflammation trigger the onset and progression of chronic lung disease at different stages of life and how can lung resilience be maintained and regeneration be promoted?; to enable discussion on aging lung between experts with different expertise, ranging from epidemiology, developmental biology, paediatric/neonatal lung biology and medicine, and adult chronic lung diseases to regenerative lung biology and medicine; to explain the developmental origins of chronic lung diseases and how to use current advanced technologies to delineate premature ageing processes; to discuss ways to promote lung intrinsic regenerative resources. to encourage basic, clinical and translational research that will bridge knowledge gaps at the intersection of translational lung research aiming to understand pathological mechanisms and the development of more effective patient stratification approaches and subsequent therapeutic strategies for chronic lung diseases that are a major global health burden.