BBT002, a tetravalent bispecific antibody targeting human IL-4R? and IL-5, demonstrated synergistic efficacy in vitro and in a porcine pancreatic elastase (PPE)-induced COPD mouse model - Amsterdam 2025

Biologics in action: clinical realities and translational innovations in airway disease therapeutics

Chair(s): Alexander Mathioudakis, Lies Lahousse

Session type: Oral presentation

BBT002, a tetravalent bispecific antibody targeting human IL-4R? and IL-5, demonstrated synergistic efficacy in vitro and in a porcine pancreatic elastase (PPE)-induced COPD mouse model

Shanshan Xu

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Late Breaking Abstract - Sustained FEV1 improvements with mepolizumab up to 104 weeks in patients with COPD and less severe airflow obstruction: Post hoc analysis of the MATINEE Phase III study

Dave Singh

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Cardiovascular safety of biologicals in patients with asthma: a nationwide cohort study

Lies Lahousse

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Utility of CompEx as a component of clinical remission in NAVIGATOR

Guy Brusselle

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Exhaled nitric oxide (FeNO) predicts response to prednisolone for asthma attacks in patients on anti-IL5/5R? therapy

Imran Howell

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Efficacy of Dupilumab in Patients with Severe Asthma and Co-existing COPD

Sammy Adam Ameri

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Predicting Optimal Timing For Biologic Switch In Severe Asthmatic Patients

Enrico Schiavi

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Clinical characteristics associated with frequent asthma exacerbations whilst on treatment with tezepelumab

Faizan Haris

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Tozorakimab exerts distinct dual pharmacology to reduce COPD epithelial remodelling

Sam Strickson

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Poster

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BBT002, a tetravalent bispecific antibody targeting human IL-4R? and IL-5, demonstrated synergistic efficacy in vitro and in a porcine pancreatic elastase (PPE)-induced COPD mouse model

Shanshan Xu

Replay

Poster

Abstract

Slides

Spatial Mapping of IL-4 / IL-13 and IL-4R? in COPD Lungs and Lymph Nodes

Jonas Erjefalt

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Discussion and Q&A

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CDN Connection Issue

The ERS Congress 2025, Amsterdam

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