Late Breaking Abstract - A Phase 1 trial to evaluate the safety, PK and target engagement of MTX-463, a monoclonal antibody inhibitor of WISP1 - Amsterdam 2025

Decoding fibrotic and inflammatory pathways in lung disease

Chair(s): Audrey Joannes, Tom Voisin

Session type: Poster session

Late Breaking Abstract - A Phase 1 trial to evaluate the safety, PK and target engagement of MTX-463, a monoclonal antibody inhibitor of WISP1

Jeffrey Bornstein

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Harnessing the power of miR200a: targeting matrix metalloproteinases to combat pulmonary fibrosis

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Advanced patient-derived lung-on-chip model replicating the human pulmonary microenvironment

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LSC - 2025 - Modeling COPD with a complex tubular distal airway model integrating the epithelial and mesenchymal compartments

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Ahmed Alshihry

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Abstract

Impact of loss-of-function mutations in the MARS1 gene on cellular stress responses in human fibroblasts

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Characterization of the systemic impact of glucocorticoid-treated exacerbation of COPD in a novel mouse model

Justine Michelle Webster

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A 3D lung Model for anti fibrotic drug discovery

Gessica Marchini

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Unveiling the impact of VEGFR2/KDR modulation on pulmonary microvascular endothelial cells in COPD/emphysema

Wenjun He

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Abstract

Impact of pulmonary arterial hypertension therapy on pulmonary artery endothelial cells harvested during right heart catheterization

Anna Sardiné

Poster

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Characterization of a novel inhaled DDR kinase-domain inhibitor in human precision-cut lung slices (PCLuS) from IPF patients

Serena Bertolini

Poster

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Pentadecanoic Acid Attenuates Pulmonary Fibrosis by Inhibiting Smad2/3 Signaling

Yeyoung Kim

Abstract

A human systemic model for concurrent evaluation of antibody-drug conjugates efficacy and interstitial lung disease risk

Guy Barbin

Poster

Abstract

SUN1 Accumulation mediates nuclear alteration, a novel hallmark driving Pulmonary hypertension.

Samuel Olapoju

Poster

Abstract

Sex-dependent Fth1 regulation shapes heterogeneous neutrophil mitochondrial dysfunction in acute lung injury

Ximing Liao

Poster

Abstract

Single-cell characterization of loss of mouse Protocadherin-1, a gene for airway hyperresponsiveness

Bao-han Ly

Poster

Abstract

Aryl hydrocarbon receptor (AhR) as a Regulator of Pulmonary Fibrosis: Gene Expression Analysis and Therapeutic Implications

Yu-cheng Wu

Poster

Abstract

IL-9-producing PP4-deficiency macrophages exacerbate lung inflammation and fibrosis via p38-SGK1 axis

Feng-ming Yang

Abstract

Lyn kinase palmitoylation promotes eosinophil activation and allergic airway inflammation via ST2 signaling.

Shenwei Gao

Poster

Abstract

Late Breaking Abstract - A Phase 1 trial to evaluate the safety, PK and target engagement of MTX-463, a monoclonal antibody inhibitor of WISP1

Jeffrey Bornstein

Poster

Abstract

CDN Connection Issue

The ERS Congress 2025, Amsterdam

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