Discovery of anti-fibrotic metabolite-sensing G protein-coupled receptors in human lung fibroblast; GPR40 agonist attenuates fibroblast activation and EMT via inhibition of TGF-? receptor signaling. - Amsterdam 2025

Metabolic pathways in lung diseases

Chair(s): Charalambos Michaeloudes, XINHUI WU

Session type: Poster session

Discovery of anti-fibrotic metabolite-sensing G protein-coupled receptors in human lung fibroblast; GPR40 agonist attenuates fibroblast activation and EMT via inhibition of TGF-? receptor signaling.

Aekkacha Moonwiriyakit

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Discovery of anti-fibrotic metabolite-sensing G protein-coupled receptors in human lung fibroblast; GPR40 agonist attenuates fibroblast activation and EMT via inhibition of TGF-? receptor signaling.

Aekkacha Moonwiriyakit

Poster

Abstract

Retinoic acid metabolism inhibits the activation of fibroblasts and the progression of idiopathic pulmonary fibrosis by activating the RA/RAR-RXR/NRF2 signaling axis

Abstract

Modulating the Lipofibroblast-to-Myofibroblast transdifferentiation: role of perilipin-1 (PLIN1) in lung fibrosis.

Elena Ortiz Zapater

Poster

Abstract

The amino acid glycine attenuates airway hyperresponsiveness associated with T2 asthma

Amlan Chakraborty

Poster

Abstract

Mitochondrial RNA modification rewires macrophage glutamine metabolism to promote septic ARDS

Lunxian Tang

Poster

Abstract

Exploring cachexia in COPD and NSCLC: AI-driven body composition and transcriptomics analysis

Luca Peschkes

Poster

Abstract

Identification of HSPG2 as a key gene modulating fatty acid metabolism in chronic thromboembolic pulmonary hypertension through multi-omics analysis

Lu Sun

Poster

Abstract

Association of Pulmonary Function, Gut Microbiota, and Amino Acid Metabolism in COPD Patients.

Durdona Saipova

Poster

Abstract

Human lung fibroblast polyamine metabolism is modulated through calcium-sensing receptor in autocrine manner

Polina Yarova

Poster

Abstract

LRP1 DEFICIENCY CHANGES LIPID METABOLISM AND AGGRAVATES LUNG FIBROSIS

Malgorzata Wygrecka

Abstract

Individualized serum proteomic and metabolomic analyses identify molecular features for phenotyping chronic obstructive pulmonary disease

Chia-li Han

Poster

Abstract

Adipose tissue deposition in lungs of patients with IPF

Wenying Lu

Poster

Abstract

Hypoxic conditions alter alveolar macrophage metabolism and function: implications for lung fibrosis

Ellen Jenkins

Poster

Abstract

Extracellular vesicles mediate macrophage dysfunction and metabolic reprogramming in idiopathic pulmonary fibrosis

Charlie Mafham

Poster

Abstract

Fibroblasts and epithelial cells display conserved alterations in metabolic pathways in IPF

Sarah H. Forde

Abstract

Phytosphingosine alleviates cigarette smoke-induced bronchial epithelial cell senescence in experimental COPD by targeting FFAR4

Yuan Zhan

Poster

Abstract

Metabolic activity of alveolar macrophages in bronchoalveolar lavage fluid in interstitial lung disease.

Takafumi Yorozuya

Poster

Abstract

Airspace monocytes can be metabolically targeted to improve phagocytosis in lung myeloid cells.

Laura Gleeson

Abstract

Urine metabolomics and its correlation with FeNO in early school-aged children in the assessment of asthma for epidemiological purposes.

Kamil Baranski

Poster

Abstract

Cholesterol is more than an innocent bystander in pulmonary fibrosis

Marissa O'callaghan

Poster

Abstract

CDN Connection Issue

The ERS Congress 2025, Amsterdam

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