Blood eosinophil gene expression and cytokine response is altered with anti-IL-5 Mepolizumab - Amsterdam 2025

Clinical insights into mechanisms defining airways disease pathogenesis and responsiveness to therapeutics

Chair(s): Cindy Barnig, Roma Sehmi

Session type: Poster session

Blood eosinophil gene expression and cytokine response is altered with anti-IL-5 Mepolizumab

Katie Raby

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Neurophenotyping cough in respiratory disease

Jenny King

Poster

Abstract

Evidence of a local negative feedback mechanism via IL-5R? shedding from airway eosinophils.

James Melhorn

Poster

Abstract

Morphological and fractal analysis of monocytes and neutrophils from smokers and ex-smokers

Amanda Carvalho

Poster

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Increased alveolar eosinophils in chronic obstructive pulmonary disease

Sophie Booth

Poster

Abstract

Distribution of Type-2 Airway Inflammation Across Different Lung Function Status

Wuping Bao

Poster

Abstract

Elevated exTreg Cells in COPD: A Novel Immunological Landscape and Potential Therapeutic Target

Jia Hou

Poster

Abstract

Changes in airway structure/function with benralizumab treatment of severe eosinophilic asthma (SEA) observed with Functional Respiratory Imaging (FRI)

Donna Carstens

Poster

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Resident and inflammatory eosinophils in early and late onset asthma.

Umberto Semenzato

Poster

Abstract

Blood eosinophil gene expression and cytokine response is altered with anti-IL-5 Mepolizumab

Katie Raby

Poster

Abstract

Immunomodulatory effects of Mepolizumab on group 2 innate lymphoid cells in patients with refractory chronic cough and eosinophilic airways disease (MUCOSA)

Takahiro Matsuyama

Poster

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The relationship between PTPRH and CEACAM5 and Th17 immune response in severe asthma patients.

Fengjia Chen

Poster

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The effect of dupilumab therapy on T regulatory cells exhaustion state in severe asthma

Tommaso Pianigiani

Poster

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Differential impact of T2 pathway biologics on IL5R-expressing mast cell progenitors in severe asthma

Michael Fricker

Poster

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The relationship between atopy, IgE levels and response to tezepelumab in severe asthma

Francesca Cefaloni

Poster

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Effects of benralizumab on T cell adhesion molecules in severe eosinophilic asthma: modulation by IL-25 and IL-33

Irene Paggi

Poster

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IL-33 and IL-25 as drivers of ICAM1 and ICAM3 expression in Th2 and regulatory T cell subsets in severe eosinophilic asthmatic patients.

Laura Bergantini

Poster

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Increased IL-33+ and ST2+ alveolar macrophages in COPD

Sophie Booth

Poster

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The lack of response to Omalizumab in patients with severe asthma is associated with IgE receptor mutations.

Fatma Emre Turan Tasolar

Poster

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The airway transcriptome in type2 cytokine biomarker-high, -intermediate and -low severe asthma

Jiashu Shen

Poster

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Factors Influencing the Response to Allergen Immunotherapy: A Retrospective Study

Yosra Bellil

Poster

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The ERS Congress 2025, Amsterdam

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