Live sessions agenda - LSC 2021 - Repair and regeneration in chronic lung disease and lung cancer

Welcome and Introduction

Reinoud Gosens (Groningen, Netherlands)

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Opening Lecture: Is human pulmonary fibrosis simply lung regeneration without a blueprint?

Naftali Kaminski (New Haven, United States of America)

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Accompanying documents

iPSC derived lung stem cells as tools to understand lung regeneration and disease

Killian Hurley (Co. Meath, Ireland)

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Accompanying documents

The journey of stem cell differentiation during alveolar regeneration

Joo-Hyeon Lee (Cambridge, United Kingdom)

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Accompanying documents

Macrophage plasticity in COPD

Joachim Schultze (Bonn, Germany)

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Accompanying documents

Epithelial-mesenchymal interactions involving FGFs

Saverio Bellusci (Giessen, Germany)

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Accompanying documents

The role of the microvascular niche in lung regeneration

Edward Morrisey (Philadelphia, United States of America)

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Accompanying documents

Poster session 1 - Group A

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Poster session 1 - Group B

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Poster session 1 - Group C

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Poster session 1 - Group D

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Poster session 2 - Group E

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Poster session 2 - Group F

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Poster session 2 - Group G

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Poster session 2 - Group H

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Early-Career delegates session - Introduction

Niki Ubags (Epalinges, Switzerland)

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The use of Pre-prints to publish your science

Darcy Wagner (Lund, Sweden)

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How to write a peer review

Pieter S. Hiemstra (Leiden, Netherlands)

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How to make me like your paper (part 1)

Martin Kolb (Hamilton (ON), Canada)

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How to make me like your paper (part 2)

Susanne Herold (Gießen, Germany)

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Early-Career delegates session - Panel discussion

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Tobacco smoking and somatic mutations in human bronchial epithelium

Sam Janes (London, United Kingdom)

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Accompanying documents

Club cells in adenocarcinoma and alveolar repair

Georgios Stathopoulos (Munich, Germany)

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Accompanying documents

Young Investigator Session The William MacNee Award

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Uncovering the cells and genes responsible for salamander limb regeneration

Nicholas Leigh (Lund, Sweden)

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Accompanying documents

Cell-matrix interactions in chronic lung disease

Janette K. Burgess (Groningen, Netherlands)

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Accompanying documents

Regulation of cell fate and integrity by mechanical signals

Sara Wick?str?m (Helsinki, Finland)

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Accompanying documents

Lung organoids reveal epithelial-mesenchymal mechanisms of lung disease and potential therapy

Carla Kim (Boston, United States of America)

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Mesenchymal stem cell therapy for severe emphysema

Pieter S. Hiemstra (Leiden, Netherlands)

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Cellular reprogramming of cancer cells to antigen-presenting cells

Filipe Pereira (Lund, Sweden)

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Accompanying documents

Awards announcement and conclusion

Reinoud Gosens (Groningen, Netherlands)

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PP101 Short-range interactions between fibrocytes and CD8+ T cells modulate the balance between tissue repair and destruction in COPD

Isabelle Dupin, France

Poster

PP102 A serum biomarker reflecting human neutrophil elastase degraded calprotectin is elevated in COPD and IPF

Annika Hummersgaard Hansen, Denmark

Poster

PP103 Dysregulation of ZFP36L1 and ZFP36L2 in asthma alters epithelial integrity and genome-wide glucocorticoid responses

Rocio Teresa Martinez-Nunez, United Kingdom

Poster

PP104 Whole transcriptome analysis on lungs of house dust mite-exposed IGF1Rdeficient mice provides new insights in allergic airway inflammation

Alfredo Urtubia, Spain

Poster

PP105 Single-cell transcriptome analysis reveals an anomalous epithelial variation and ectopic inflammatory response in COPD

Naoaki Watanabe, Japan

Poster

PP106 Identification of HuR-specific RNA interactome in TGFß1-activated fibroblasts in response to cigarette smoke

Sofia Winslow, Sweden

Poster

PP107 3D printing aids simultaneous isolation of proximal and distal lung epithelial progenitors from individual mice

Hani N. Alsafadi, Sweden

Poster

PP108 Role of TRIM-16-mediated lysophagy in COPD pathogenesis

Yusuke Hosaka, Japan

Poster

PP109 Coxsackie and Adenovirus Receptor (CAR) controls lung epithelial cell responses to inflammation

Elena Ortiz Zapater, United Kingdom

Poster

PP110 Modulation of the TGF-ß-induced epithelial-to-mesenchymal transition by panselective PDE inhibitors in A549 cells

Katarzyna Wójcik-Pszczola, Poland

Poster

PP111 PGE2 and PGI2 restore defective lung epithelial progenitors induced by cigarette smoke

Xinhui Wu, Netherlands

Poster

PP112 Itaconate regulates responses to inhaled aeroallergen

Gesa Albers, United Kingdom

Poster

PP113 Epidermal growth factor receptor in airway remodelling during allergic airway disease divergent roles during early life and adulthood?

Helen Stölting, United Kingdom

Poster

PP114 Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model

Ian Hawthorne, Ireland

Poster

PP115 COL4A3 degradation predicts anti-IgE response in severe asthma

Markus Weckmann, Germany

Poster

PP116 Associations between pediatric asthma and adult lung diseases

Nirmin Juber, Taiwan

Poster

PP117 Household use of biomass fuel is associated with childhood wheeze and eczema: a cross sectional study of rural communities in Kandy, Sri Lanka

Olivia Lall, Australia

Poster

PP118 Ambient PM2.5 Exposure and Respiratory Disease Hospitalization in Kandy, Sri Lanka

Gayan Bowatte, Sri Lanka

Poster

PP119 COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding

Sai Sneha Priya Nemani, Germany

Poster

PP120 Smoking alters gene expression and methylation patterns in asthma patient nasal epithelium

Karosham (Diren) Reddy, Australia

Poster

PP121 Gaq/11 and Ga12/13 promote pulmonary fibrosis by driving distinct myofibroblast functions

Amanda Goodwin, United Kingdom

Poster

PP122 AT2 cell delivery using rECM microcarriers for COPD treatment

Deniz Ali Bölükbas, Sweden

Poster

PP123 Dimethyl fumarate attenuates lung inflammation and oxidative stress induced by chronic exposure to diesel exhaust particles in mice

Isabella Cattani-Cavalieri, Netherlands

Poster

PP124 Establishment of a human in vitro model for airway epithelial repair and regeneration

Ashesh Chakraborty, Germany

Poster

PP125 Glycogen synthase kinase-3 inhibition by CHIR99021 promotes alveolar epithelial cell proliferation and lung regeneration in acute lung injury

Raquel Fernandes, Portugal

Poster

PP126 RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation

Habibie Habibie, Netherlands

Poster

PP127 Three-dimensional niches for the physiological-like expansion of a lung mesenchymal stromal cell subpopulation

Arturo Ibáñez Fonseca, Sweden

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PP128 Investigating the role of vitamin A intake and retinoic acid signalling in lung homeostasis and repair-A multidisciplinary approach

Róisín Mongey, United Kingdom

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PP129 Safety evaluation of cancer immunotherapy in a lung-on-chip model: the therapeutic FOLR1 targeting T Cell Bispecific antibody

Giulia Raggi, Switzerland

Poster

PP130 Spatial characteristics of CD169+ resident conducting airway macrophages during Aspergillus fumigatus-induced inflammation

Marina Shevchenko, Russia

Poster

PP131 Macrophages in lung adenocarcinoma

Giannoula Ntaliarda, Greece

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PP132 Reversible fetal tracheal occlusion in mice: a novel transuterine method

Nilhan Torlak, Turkey

Poster

PP133 IGF1R acts in the tumor microenvironment as a cancer-promoting factor facilitating the implantation and progression of lung metastasis

Elvira Alfaro Arnedo, Spain

Poster

PP134 Mapping of Kras mutations during chemical carcinogenesis

Sabine Behrend, Germany

Poster

PP135 Mutational RNA signatures in environmentally-induced lung adenocarcinoma

Georgia A. Giotopoulou, Germany

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PP136 Preclinical evaluation of IL-1ß inhibition against KRAS-mutant lung adenocarcinoma

Georgios Skiadas, Greece

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PP137 Airway cells in adult lung homeostasis and carcinogenesis

Magda Spella, Greece

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PP138 Regulation of PA200 in lung cancer

Ayse Seda Yazgili, Germany

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PP201 Therapeutic targeting of iBALT induces lung regeneration in COPD

Thomas Conlon, Germany

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PP202 Recreating the 3D environment for airway fibroblasts and epithelial cells with lung extracellular matrix derived hydrogels

Roderick H.J. de Hilster, Netherlands

Poster

PP203 Club cell functions as a Wnt-responsive progenitor for tissue repair in COPD

Yan Hu, USA

Poster

PP205 Effect of mTOR inhibition in a 3D in vitro model of alveolar epithelium and epithelial regeneration

Manuela Platé, United Kingdom

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PP206 Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids

Victoria Ptasinski, Sweden

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PP207 Targeting p16INK4a in alveolar type 2 cells to induce endogenous lung alveolar regeneration

Bruno Ribeiro Baptista, France

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PP208 SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis

Carmen Veith, Germany

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PP209 Mitochondrial DNA stress activates MHC class I antigen presentation and CD8+ Tcell immunity: implications for pulmonary fibrosis

Xinyuan Wang, Germany

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PP211 Galectin-3 is elevated following nintedanib treatment

Gali Epstein Shochet, Israel

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PP212 The Anti-Fibrotic Drug Nintedanib Promotes Repair Macrophages

Carolin Koss, Germany

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PP213 Adoptive transfer of hepatocyte growth factor transfected T cells in a bleomycin injured murine lung model

Seyran Mutlu, Switzerland

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PP214 Human precision-cut lung slices generated from excess donor lungs as a model for IPF and drug screening

John Stegmayr, Sweden

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PP215 The effect of long-term personal air pollution exposure on the inflammatory mediators in Idiopathic Pulmonary Fibrosis

Ioannis Tomos, Greece

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PP216 Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity

Muzamil Majid Khan, Germany

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PP217 Modeling idiopathic pulmonary fibrosis on a lung-on-chip

Lea de Maddalena, Switzerland

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PP218 Direct effects of cigarette smoke in pulmonary arterial cells: Implications in arterial remodeling and vascular tone maintenance

Javier Sevilla-Montero, Spain

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PP219 Development and Validation of a Novel Prognostic Nomogram for COPD patients with Pulmonary Hypertension

Dansha Zhou, China

Poster

PP220 Hypercoagulability in patients with stable COPD assessed by coagulation factor levels

Chris Kyriakopoulos, Greece

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PP221 EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury

Huy Le, Germany

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PP222 Forkhead Box F1 as a mediator of Wnt signaling in human lung endothelial cells

Gabriëla Edel, Netherlands

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PP223 N-Acetyl cysteine rescues neonatal lethality caused by HRas/NRas deficiency by improving lung maturation and decreasing oxidative stress

Rocío Fuentes Mateos, Spain

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PP225 Development of a 3D in vitro co-culture model of the airway mucosa using human primary cells

Cinta Iriondo, Netherlands

Poster

PP226 Decellularized extracellular matrix hydrogels for human airway organoid culture

Sinem Tas, Sweden

Poster

PP227 Paper-based biosensor for the detection of sepsis murine using MMP9 and a9ß6, integrons RI Class1 and R2 Class 2 peptides

Nuha Alekhmimi, Saudi Arabia

Poster

PP228 Chest CT findings on admission of COVID-19 pneumonia and its association with disease severity and duration of illness: a retrospective study

Eleanor Dela Pena, Philippines

Poster

PP229 Clinical profile of 116 patients undergoing post-COVID follow-up - A prospective study

Pranav Modi, India

Poster

PP230 Functional profiling and visualization of stromal cell dynamics in the influenza virus infected lung

Julie Worrell, United Kingdom

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PP231 Released mediators in ex vivo 3D-model of lung fibrosis correspond to elevated serum biomarkers in IPF

Dimitrios Kalafatis, Sweden

Poster

PP232 IL11 negatively impacts adult lung alveolar organoid formation

Rosa K. Kortekaas, Netherlands

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PP233 Crosstalk between lung fibroblasts and mast cells is modified by alveolar extracellular matrix and influences epithelial migration

Anna-Karin Larsson-Callerfelt, Sweden

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PP234 Lung-on-a-chip device for modelling of ventilator induced lung injury

Emil Rehnberg, Sweden

Poster

PP236 Elastin-like-recombinamer cryogel as a platform for lung regeneration

Zackarias Söderlund, Sweden

Poster

PP237 D-dopachrome tautomerase contributes to lung epithelial repair via ACKR3- dependent Akt signalling

Shanshan Song, Netherlands

Poster

PP238 Role of mitochondrial function of lung mesenchymal stem cells in idiopathic pulmonary fibrosis

Joan Truyols, Spain

Poster

PP239 Decellularised porcine pleural patches for management of prolonged alveolar air leaks

Trisha Vikranth, United Kingdom

Poster

PP240 COL4A3 degradation is increased in severe, type 2 exacerbating asthmatics

Markus Weckmann, Germany

Poster

PP301 The role of the systemic inflammation in bronchiectasis exacerbation frequency

Kseniia Suska, Ukraine

Poster

PP302 The relationship between the level of C-reactive protein and the general cardiovascular risk in patients with COPD and hypertension

Olha Boiko, Ukraine

Poster

PP303 Effects of mild to moderate asthma in pregnancy on the wellbeing of mother and newborn; A case control study from Sri Lanka

Duminda Yasaratne, Sri Lanka

Poster

PP304 The effect of exercises on flat and sloping levels on muscle mass and functional capacity in chronic obstructive pulmonary disease patients

Samira Nakhaie, Iran

Poster

PP305 Can Hematological Ratios Predict Outcome of COVID-19 Patients? Egyptian Multicentric Study

Mai Aly, Egypt

Poster

PP306 Submicroscopic changes of type I alveolocytes in the early stages of experimental diabetes mellitus

Yuliya Fedorchenko, Ukraine

Poster

PP307 The role of microalbuminuria (MAB) in patients admitted for an Acute COPD Exacerbation (AECOPD)

Chris Kyriakopoulos, Greece

Poster

PP308 Endothelial injury in Chronic Obstructive Pulmonary Disease assessed by microalbuminuria (MAB) and von Willebrand factor levels and activity

Chris Kyriakopoulos, Greece

Poster

PP309 Effect of elexacaftor-tezacaftor-ivacaftor on pulmonary and endothelial function in a patient with advanced cystic fibrosis

Saa Rink, Slovenia

Poster

PP310 Association of testosterone with lung function in patients with chronic obstructive lung disease

Abir Hedhli, Tunisia

Poster

PP311 Nontypeable Haemophilus influenzae supresses SP-B and SP-C expression in alveolar epithelial type II cells

Hannah Sophie Stodden, Germany

Poster

PP312 Diagnosis of non severe pulmonary embolism

Salma Aït Batahar, Morocco

Poster

PP313 Agreement between expert sonographers and artificial intelligence in the evaluation of lung ultrasound data acquired from COVID-19 patients

Libertario Demi, Italy

Poster

YI401 - A comprehensive guide to pulmonary mesenchymal populations in the healthy and IPF lung

Simon Coyle Rowan (Dublin, Ireland)

Poster

YI402 - Host response towards decellularised lung extracellular matrix reinforced bioinks for 3D bioprinting lung tissue for transplantation

Martina M. De Santis (Lund, Sweden)

Poster

YI403 - cAMP response element-binding protein mediates immune-evasion of KRASmutant lung adenocarcinoma

Georgia A. Giotopoulou (Munich, Germany)

Poster

YI404 - Pluripotent stem cell derived airway cholinergic neurons for disease modelling of neuroplasticity in asthma

Pien Goldsteen (Groningen, Netherlands)

Poster

YI405 - Use of differentiated primary human airway epithelial models to study SARSCoV-2 infection biology and pathogenesis

Ying Wang (Leiden, Netherlands)

Poster

CDN Connection Issue

Lung Science Conference 2021

LSC 2021 - Repair and regeneration in chronic lung disease and lung cancer

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