Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD) - Amsterdam 2025

Preclinical insights into rare diseases

Chair(s): Gimano Amatngalim, Killian Hurley

Session type: Poster session

Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD)

Lucy Kirwan

EVENTS HOME

Poster
Abstract

Previous presentation

Next presentation

Session content

Baicalein Attenuates CD8? T Cell-Mediated Cytotoxicity Against Bronchial Epithelial Cells by Inhibiting Perforin and Granzyme B

Xinru Xiao

Abstract

A primary ciliary dyskinesia in vitro model using CRISPR-edited clonal primary epithelial cells

Elizabeth Haughey

Poster

Abstract

Late Breaking Abstract - scRNA-seq analysis reveals that the fibrotic lung milieu amplifies pro-fibrotic effects of pulmonary macrophage transplantation by inducing recipient macrophages to adopt fibrotic characteristics and interact with immune cells via fibrotic signaling

Jun Ikari

Poster

Abstract

Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD)

Lucy Kirwan

Poster

Abstract

Alpha-1 Antitrypsin deficiency intensifies experimental mucosecretory disease in a hybrid mouse model

Gary P. Anderson

Poster

Abstract

CFTR genotype affects miRNA expression profile in response to innate immunity triggers in airway epithelial cells.

Aleksandra Szczepankiewicz

Poster

Abstract

Alteration of Th1/Th2 axis in post-covid-19 pulmonary fibrosis

Geetanjali Bade

Poster

Abstract

NEUTROPHIL EXTRACELLULAR TRAPS MEASUREMENT IN BRONCHOALVEOLAR LAVAGE FLUID OF PATIENTS WITH INTERSTITIAL LUNG DISEASE: A POSSIBLE BIOMARKER IN FIBROSIS?

Bianca Peixoto

Poster

Abstract

Identification of novel markers of progression in Idiopathic Pulmonary Fibrosis (IPF) and Chronic Hypersensitivity Pneumonitis (CHP)

Megan Mckean

Abstract

Resolution of Inflammation is Impaired in the Sugen-Hypoxia Mouse Model of Pulmonary Arterial Hypertension

Chloe Landy

Poster

Abstract

Transcriptomic effects of Azithromycin on airway basal cells in CCDC39 primary ciliary dyskinesia

Zofia Varenyiova

Poster

Abstract

Responsiveness of ciliary movement to ATP in primary ciliary dyskinesia with a long deletion in DRC1

Miki Abo

Poster

Abstract

RNA editing to correct the Z-allele in models of alpha-1 antitrypsin deficiency allows for maintenance of acute phase response

Maria Strakosha

Poster

Abstract

Seralutinib demonstrates in vitro reduction of vascular inflammatory drivers underlying pulmonary hypertension

Zhaoqing Ding

Poster

Abstract

Double-stranded RNA-induced macrophage pyroptosis: molecular mechanisms and impact on fibroblast activation

Lara Di Leonardo

Poster

Abstract

Inflammatory pattern in upper airway epithelium of Cystic Fibrosis patients

Elena Pohl

Poster

Abstract

TGF-?/Smad signalling through Nrf2 activation which alters the fibrotic phenotype in experimental pulmonary fibrosis

Arindam Bhattacharyya

Abstract

Bone marrow Mesenchymal Stromal Cells stimulated with Pulsed Electromagnetic Fields for the treatment of pulmonary fibrosis

Sara Bozzini

Poster

Abstract

Late Breaking Abstract - SOAT1-Mediated Lipid Dysregulation Drives PHMG-Induced Pulmonary Fibrosis: Therapeutic Potential of Avasimibe

Yuchao Ding

Poster

Abstract

CDN Connection Issue

The ERS Congress 2025, Amsterdam

#{title}