BCLXL-PROTAC as a senolytic therapy in COPD alveolar type II cells - Amsterdam 2025

Mechanisms of accelerated ageing in lung diseases and anti-ageing interventions

Chair(s): Mareike Lehmann, Tamara Blake

Session type: Poster session

BCLXL-PROTAC as a senolytic therapy in COPD alveolar type II cells

Yiling Guo

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Lifetime small airways function trajectories: early life risk factors and future COPD

Jiacheng Liu

Poster

Abstract

Effects of Nerandomilast on Alveolar Type 2 Cell Senescence and Fibrosis-Related PATS Accumulation in Pulmonary Fibrosis

Shun Inukai

Poster

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The impact of oxidative stress on the development of bronchopulmonary dysplasia in pretern infants

Adelina Procopi

Poster

Abstract

Increased immunosenescence leads to airway remodeling in COPD

Irfan Rahman

Abstract

cGAS-STING signaling pathway is involved in IL-17A-induced Cellular Senescence and lung fibrosis

Irfan Rahman

Abstract

Endothelial senescence as a key driver of COPD-Induced Pulmonary Hypertension

Huilin Yu

Poster

Abstract

Cellular senescence in an aged murine bleomycin-induced pulmonary fibrosis model.

Maya Renfrew

Abstract

Investigating How Telomere-Related Mutations Influence iPSC Reprogramming in a Model of Short Telomere Associated Pulmonary Fibrosis.

Amy Duffy

Poster

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Anti-fibrotic and anti-senescent effects of telomerase modRNA in human pulmonary fibrosis

Christina Hesse

Poster

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Prophylactic quercetin attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells

Lu Yin

Poster

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Inhibition of senescence-associated ?-Galactosidase by Amiloride in senescent airway epithelial cells

Shyreen Hassibi

Poster

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Establishing a robust model for TGF? induced endothelial damage and its translation to chronic lung disease

Vanessa Ho

Poster

Abstract

BCLXL-PROTAC as a senolytic therapy in COPD alveolar type II cells

Yiling Guo

Poster

Abstract

A novel ECM human lung proteome atlas of healthy aging and COPD.

Delphine Beaulieu

Poster

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Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD

Justine Devulder

Poster

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The Role of TFEB in IPF Pathogenesis: Regulation of Alveolar Type II Epithelial Cell Stemness

Tomoya Maruyama

Poster

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Accelerated epigenetic age in Bronchiectasis

Pau Marrades Segura

Poster

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Premature alveolar epithelial and endothelial ageing with vascular muscularization after neonatal oxidative stress is associated to dysregulation of NOTCH3 and NOTCH4 activity

Mohammad Amin Mahjoub

Abstract

Assessing Smoking-Related Age Acceleration and the Role of Diet: A Cross-Sectional Study Using Epigenetic Clocks

Azaan Zaki

Poster

Abstract

Senolytic Targeting of Airway Epithelial Senescence Disrupts Type 2 Inflammatory Signaling: A Preclinical Strategy for Refractory Asthma Treatment

Jian Wu

Poster

Abstract

CDN Connection Issue

The ERS Congress 2025, Amsterdam

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