Senolytic Targeting of Airway Epithelial Senescence Disrupts Type 2 Inflammatory Signaling: A Preclinical Strategy for Refractory Asthma Treatment - Amsterdam 2025

Mechanisms of accelerated ageing in lung diseases and anti-ageing interventions

Chair(s): Mareike Lehmann, Tamara Blake

Session type: Poster session

Senolytic Targeting of Airway Epithelial Senescence Disrupts Type 2 Inflammatory Signaling: A Preclinical Strategy for Refractory Asthma Treatment

Jian Wu

EVENTS HOME

Poster
Abstract

Previous presentation

Next presentation

Session content

Lifetime small airways function trajectories: early life risk factors and future COPD

Jiacheng Liu

Poster

Abstract

Effects of Nerandomilast on Alveolar Type 2 Cell Senescence and Fibrosis-Related PATS Accumulation in Pulmonary Fibrosis

Shun Inukai

Poster

Abstract

The impact of oxidative stress on the development of bronchopulmonary dysplasia in pretern infants

Adelina Procopi

Poster

Abstract

Increased immunosenescence leads to airway remodeling in COPD

Irfan Rahman

Abstract

cGAS-STING signaling pathway is involved in IL-17A-induced Cellular Senescence and lung fibrosis

Irfan Rahman

Abstract

Endothelial senescence as a key driver of COPD-Induced Pulmonary Hypertension

Huilin Yu

Poster

Abstract

Cellular senescence in an aged murine bleomycin-induced pulmonary fibrosis model.

Maya Renfrew

Abstract

Investigating How Telomere-Related Mutations Influence iPSC Reprogramming in a Model of Short Telomere Associated Pulmonary Fibrosis.

Amy Duffy

Poster

Abstract

Anti-fibrotic and anti-senescent effects of telomerase modRNA in human pulmonary fibrosis

Christina Hesse

Poster

Abstract

Prophylactic quercetin attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells

Lu Yin

Poster

Abstract

Inhibition of senescence-associated ?-Galactosidase by Amiloride in senescent airway epithelial cells

Shyreen Hassibi

Poster

Abstract

Establishing a robust model for TGF? induced endothelial damage and its translation to chronic lung disease

Vanessa Ho

Poster

Abstract

BCLXL-PROTAC as a senolytic therapy in COPD alveolar type II cells

Yiling Guo

Poster

Abstract

A novel ECM human lung proteome atlas of healthy aging and COPD.

Delphine Beaulieu

Poster

Abstract

Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD

Justine Devulder

Poster

Abstract

The Role of TFEB in IPF Pathogenesis: Regulation of Alveolar Type II Epithelial Cell Stemness

Tomoya Maruyama

Poster

Abstract

Accelerated epigenetic age in Bronchiectasis

Pau Marrades Segura

Poster

Abstract

Premature alveolar epithelial and endothelial ageing with vascular muscularization after neonatal oxidative stress is associated to dysregulation of NOTCH3 and NOTCH4 activity

Mohammad Amin Mahjoub

Abstract

Assessing Smoking-Related Age Acceleration and the Role of Diet: A Cross-Sectional Study Using Epigenetic Clocks

Azaan Zaki

Poster

Abstract

Senolytic Targeting of Airway Epithelial Senescence Disrupts Type 2 Inflammatory Signaling: A Preclinical Strategy for Refractory Asthma Treatment

Jian Wu

Poster

Abstract

CDN Connection Issue

The ERS Congress 2025, Amsterdam

#{title}