Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD - Amsterdam 2025

Mechanisms of accelerated ageing in lung diseases and anti-ageing interventions

Chair(s): Mareike Lehmann, Tamara Blake

Session type: Poster session

Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD

Justine Devulder

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BCLXL-PROTAC as a senolytic therapy in COPD alveolar type II cells

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Abstract

A novel ECM human lung proteome atlas of healthy aging and COPD.

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Poster

Abstract

Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD

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Poster

Abstract

The Role of TFEB in IPF Pathogenesis: Regulation of Alveolar Type II Epithelial Cell Stemness

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Abstract

Accelerated epigenetic age in Bronchiectasis

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Abstract

Premature alveolar epithelial and endothelial ageing with vascular muscularization after neonatal oxidative stress is associated to dysregulation of NOTCH3 and NOTCH4 activity

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Abstract

Assessing Smoking-Related Age Acceleration and the Role of Diet: A Cross-Sectional Study Using Epigenetic Clocks

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Poster

Abstract

Senolytic Targeting of Airway Epithelial Senescence Disrupts Type 2 Inflammatory Signaling: A Preclinical Strategy for Refractory Asthma Treatment

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Poster

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CDN Connection Issue

The ERS Congress 2025, Amsterdam

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