2005 - Adaptations to Hypoxia

Basic research has started unravelling the biology of gene regulation in response to hypoxia. In addition, the hypoxic stimulus appears to exert different effects according to the way it is delivered (continuous vs. intermittent hypoxia). This new information is very important for clinicians, especially those dealing with respiratory insufficiency and sleep disordered breathing, but also for exercise and high-altitude physiologists. The purpose of this Research Seminar is to fill the gap between basic and clinical science by gathering experts from different research fields (cell biology, exercise, high altitude medicine, clinical respiratory research). A large amount of time will be dedicated to discussion, with special focus on the potential impact of recently described cell mechanisms for diagnosis and treatment of respiratory disease.

2005 - Adaptations to Hypoxia

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Introduction: Oxygen transport and oxygen utilisation: an integrated view

P. D. Wagner (La Jolla, United States of America)

Slides

Accompanying documents

HIF Gene expression and Hypoxia signalling

J. Pouysségur (Nice, France)

Accompanying documents

Acute hypoxia signaling in the carotid body: role of 02-sensitive ion channels

J. Lopez-Barneo (Seville, Spain)

Slides

Accompanying documents

Disruption of the HIF-1 pathway in cancer cells

L. Poellinger (Stockholm, Sweden)

Slides

Accompanying documents

Neurobehavioural consequences of intermittent hypoxia

B. Row (Louisville, United States Of America)

Slides

Impact of intermittent hypoxia on cardiovascular morbidity and mortality

A. Agusti (Palma de Mallorca, Spain)

Slides

Accompanying documents

Hypoxia and the bone marrow

M. Bonsignore (Palermo, Italy)

Slides

Accompanying documents

Pulmonary vascular remodeling and stem cells

N. Voelkel (Denver, Co, United States Of America)

Slides

Accompanying documents

Adaptation of VO2, oxygen sensing and ROS signalling during hypoxia

P. Schumacker (Chicago, United States Of America)

Accompanying documents

Nutriotional problems in COPD: interference of hypoxia with the energetic metabolism

A. Schols (Maastricht, The Netherlands)

Slides

Muscle dysfunction in COPD

A. Agusti (Palma De Mallorca, Spain)

Slides

Accompanying documents

Oxygen sensing in the pulmonary circulation

P. Schumacker (Chicago, United States Of America)

Accompanying documents

Hypoxic and non-hypoxic induction mechanisms of HIF-1alpha

J. Pouysségur (Nice, France)

Accompanying documents

2005 - Adaptations to Hypoxia

2005 - Adaptations to Hypoxia

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